The 24-year-old made beating the 17-time grand slam champion look snug as he progressed into the semifinals of the event.
Medvedev has now received three of his final 4 conferences in opposition to Djokovic, who can nonetheless qualify for the knockout phases if he beats Alexander Zverev in his subsequent match.
The Serb merely made too many unforced errors — 24 in complete — and was matched in each division by his opponent who didn’t comprise his smile after ending the job.
“I like to play Novak (Djokovic), first of all because he is one of the greatest champions in history,” Medvedev stated after the match.
“When I was 8 years old, I was already watching him on TV winning grand slams. He was still young. It is always a dream come true to play against him.
“Of course, (I’m) actually completely satisfied to beat him. I used to be serving good and taking part in protected sufficient in an important moments. That is why I acquired the win.”
Djokovic hopes alive
Djokovic had dictated the early exchanges but it was Medvedev who broke first in the opening set after a mammoth game of over 11 minutes.
It proved to be the turning point in the match with the Russian going on to win seven consecutive games.
The hill was simply too steep for Djokovic to recover and he was facing a man in inspirational form.
“To be fully sincere, I’m certain he did not play his greatest at this time. But nonetheless, it occurs for everyone,” Medvedev added.
“I at all times say the Big Three are the champions as a result of it occurs much less for them than for different gamers. It remains to be robust to beat them, even on their unhealthy days so I’m actually completely satisfied in regards to the win. I’m feeling good (and) assured proper now.”
It’s a really completely different story from final 12 months, when Medvedev didn’t win any of his group stage matches on the season-ending spectacle.
Medvedev will face both Rafael Nadal or Stefanos Tsitsipas within the semifinals, with the pair going face to face on Thursday.
Earlier on Wednesday, Zverev stored his hopes within the event alive by beating Diego Schwartzman in three units — 6-3 4-6 6-3.
The 2018 champion now faces Djokovic in his ultimate round-robin match on Friday, with the winner progressing to the following spherical.
“That’s most likely probably the most tough match-up I might have, taking part in Novak,” Zverev said after his victory.
“I stated from the start of the week in each match I’m going to enhance. I wanted to get again into the rhythm. I went in with the mindset that I needed to win and I’ll do this once more on Friday.”